Lipitor, Crestor, Pravachol, Zocor, Lescol, Mevacor, and others


Statins inhibit the enzyme HMG CoA reductase—a key step in the hepatic synthesis of cholesterol. The reduction of cholesterol synthesis subsequently increases the liver’s removal of circulating LDL cholesterol.

Blocking HMG-CoA reductase also prevents CoQ-10 production

Drug-Induced Nutrient Depletions


Statins inhibit the enzyme HMG CoA reductase.

Symptoms of Depletion
  • Lack of energy
  • Muscle pain and weakness
  • Congestive heart failure
  • High blood pressure
  • Angina
  • Mitral valve prolapse
  • Cardiac
  • Arrhythmias
  • Generalized weakening of the immune system


Ortho Molecular CoQ10
Additional Supplementation

Fish oil1: 500–1000 mg EPA+DHA/day

Dietary Supplements that have Potential for Interactions with Drug (or Drug Class)**

St. John’s Wort and Garlic
(containing allicin):
St. John’s Wort may increase the metabolism (cytochrome P450 ~ CYP3A4) of some of the statins leading to decrease serum concentrations of these drugs and possibly diminished effectiveness.

Vitamin A:
Long term use of cholesterol-lowering drugs may increase vitamin A levels in the blood. Vitamin A levels may need to be monitored in some people.

Red Yeast Rice:
Red yeast rice contains lovastatin which also lowers blood cholesterol levels. This supplement should not be taken with cholesterol lowering drugs unless under the supervision of a healthcare professional.

*Suggested supplements that may support overall health and are not at all intended to replace any prescription medications.

**These supplements listed may have the potential to interact with the drug or drug class. Use caution or avoid these supplements unless approved by your physician or preferred health care provider.

1 Omega-3 fatty acids EPA and DHA support heart health.