Estrace, Premarin and Prempro and others


Hormone replacement therapy is used to replace female hormones that are no longer produced after menopause.

Increased vitamin metabolism.

Drug-Induced Nutrient Depletions
  • Folic acid
  • Magnesium
  • Vitamin D
  • Vitamin B6
  • Vitamin B12
  • Calcium
  • Zinc
Symptoms of Depletion

Folic Acid

  • Megaloblastic anemia
  • Birth defects
  • Cervical dysplasia
  • Elevated homocysteine
  • Headache
  • Fatigue
  • Hair loss
  • Increased infections


  • Muscle cramps
  • Weakness
  • Insomnia
  • Loss of appetite
  • GI disorders
  • Kidney stones
  • Osteoporosis
  • Nervousness
  • Restlessness
  • Depression
  • Anxiety
  • Confusion
  • Fatigue
  • High blood pressure

Vitamin D

  • Osteopenia
  • Osteoporosis
  • Insomnia
  • More illness

Vitamin B6

  • Depression
  • Low energy

Vitamin B12

  • Fatigue
  • Peripheral neuropathy
  • Tongue and mouth irregularities
  • Macrocytic anemia
  • Depression
  • Confusion
  • Memory loss
  • Easy bruising
  • Dermatitis
  • Loss of appetite


  • Muscle cramps
  • Heart palpitations
  • High blood pressure
  • Brittle and soft bones
  • Insomnia
  • Leg and back pain


  • Acne
  • Impaired sense of smell and taste
  • Delayed wound healing
  • Decreased immunity
  • Frequent infections
  • Depression
  • Night blindness
  • Problems with hair, skin and nail


Ortho Biotic
Additional Supplementation

Alpha Based Multivitamin

Dietary Supplements that have Potential for Interactions with Drug (or Drug Class)**

Calcium and Vitamin D:
Calcium and Vitamin D may increase absorption of hormone replacements. These supplements are recommended to improve bone mineral density during estrogen therapy.

Zinc and Magnesium:
Excretion of these minerals is reduced by hormone replacement therapy.

Red Clover Extract and Soy Isoflavones:
These supplements may interfere with the activity or absorption of hormone replacement therapy.

St. John’s Wort:
St. John’s Wort may alter hormone metabolism including estrogen and progesterone. This supplement is not recommended during hormone replacement therapy.

The stimulating effects of caffeine may be increased due to inhibition of metabolism or clearance of caffeine by hormone replacement therapy.

*Suggested supplements that may support overall health and are not at all intended to replace any prescription medications.

**These supplements listed may have the potential to interact with the drug or drug class. Use caution or avoid these supplements unless approved by your physician or preferred health care provider.