Abilify, Seroquel, Zyprexa, Risperdal, Invega, Geodon, Haldol, Prolixen and others.


Antipsychotics block receptors for the neurotransmitters, dopamine, serotonin or both. They can reduce the symptoms of schizophrenia, decrease agitation and or aggression associated with other psychiatric conditions and may stabilize mood in bipolar disease.

Drug-Induced Nutrient Depletions

Vitamin B2 (riboflavin)

Symptoms of Depletion
  • dryness and cracking of the skin around the nose and mouth.
  • red, dry tongue – called magenta tongue.
  • skin rash.
  • anaemia.
  • weakness and fatigue.
  • vision problems - red, sore or watering eyes, blurred vision and sensitivity to light.


Vitamin B2
Additional Supplementation

Vitamin C1: 250–500 mg/day

Dietary Supplements that have Potential for Interactions with Drug (or Drug Class)**

Echinacea may inhibit the human drugmetabolizing enzyme CYP1A2 leading to decreased clearance (increased blood levels) of Zyprexa or Clozaril and this increased potential for side effects.

Evening Primrose Oil:
Seizures have been reported in people with schizophrenia treated concomitantly with phenothiazine drugs (Chlorpromazine, Fluphenazine, Perphenazine, Promazine, and Thioridazine) and evening primrose oil.

Goldenseal can inhibit cytochrome P450 2D6 (CYP2D6) and might increase level and potential for side effects from a number of antipsychotic medications including Zyprexa, Risperdal, Abilify, Haldol and others.

Ginseng may exacerbate some psychiatric conditions including hysteria, mania, and schizophrenia and thus compromise the therapeutic benefit of antipsychotics. Ginseng may also inhibit some of the drug metabolizing enzymes responsible for clearance of a number of antipsychotic drugs.

Gingko Biloba:
Ginkgo has been reported to cause seizures or lower seizure threshold. Thus, in combination with drugs that lower seizure threshold (including antipsychotics) the combination might significantly increase risk of seizures.

St. John’s Wort:
St John’s Wort in combination with other psychotropic drugs, including antipsychotics, may lead to unpredictable effects. St. John’s Wort is known to cause photosensitivity therefore using it with other photosensitizing drugs such as phenothiazine antipsychotic drugs may increase the risk of photosensitivity.

*Suggested supplements that may support overall health and are not at all intended to replace any prescription medications.

**These supplements listed may have the potential to interact with the drug or drug class. Use caution or avoid these supplements unless approved by your physician or preferred health care provider.

1 Vitamin C taken in adjunct with atypical antipsychotics may reduce oxidative stress.