Cymbalta, Effexor, Lexapro, Elavil, Paxil, Prozac, Norpramin, Remeron, Wellbutrin, Zoloft, Pristiq, Emsam and others


This class of medications increases the levels of one of more of the biogenic amines (e.g. norepinephrine, serotonin, dopamine) in the central nervous system. Clinical improvement from antidepressant therapy generally takes 3–6 weeks.

Drug-Induced Nutrient Depletions

SSRIs deplete folic acid.

Symptoms of Depletion

Folic Acid

  • Megaloblastic anemia
  • Birth defects
  • Cervical dysplasia
  • Elevated homocysteine
  • Headache
  • Fatigue
  • Hair loss
  • Increased infections


Folic Acid
Additional Supplementation


Dietary Supplements that have Potential for Interactions with Drug (or Drug Class)**

Melatonin may interact with medications that inhibit serotonin reuptake including a number of antidepressant medications (SSRIs, tricyclic antidepressants, venlafaxine, etc). Endogenous melatonin levels are reduced by SSRI medications.

St. John’s Wort and 5-HTP:
St John’s Wort and other supplements such as 5-HTP, in combination with other drugs that increase CNS serotonin levels (SSRIs, tricyclic antidepressants, venlafaxine, MAO inhibitors), can increase the risk of serotonergic side effects, including serotonin syndrome.

Studies suggest SAM-e may augment the actions of antidepressant drugs in patients who are refractory to, or do not get full remission from their antidepressants.

*Suggested supplements that may support overall health and are not at all intended to replace any prescription medications.

**These supplements listed may have the potential to interact with the drug or drug class. Use caution or avoid these supplements unless approved by your physician or preferred health care provider.