Aldomet, Altace, Calan, Cardura, Cozaar, Hydrodiuril, Lotensin, Norvasc, Vasotec and others


ACE Inhibitors, Angiotensin Receptor Blockers (ARBs), Calcium Channel Blockers, Beta Blockers, Diuretics

The major classes of anti-hypertensive drugs are beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, and thiazide diuretics. These drugs work to reduce blood pressure by decreasing total peripheral resistance or by reducing cardiac output, or both.

ACE Inhibitors cause an increased excretion of zinc.

Beta Blockers depletion may be due to the inhibition of two CoQ-10 enzymes succinoxidase and NADH-oxidase; these actions could depress myocardial function.

Drug-Induced Nutrient Depletions
  • Zinc
  • CoQ-10
Symptoms of Depletion


  • Acne
  • Impaired sense of smell and taste
  • Delayed wound healing
  • Decreased immunity
  • Frequent infections
  • Depression
  • Night blindness
  • Problems with hair, skin and nails
  • Component of insulin
  • Needed for thyroid conversion of T4 to T3


  • Lack of energy
  • Muscle pain and weakness
  • Congestive heart failure
  • High blood pressure
  • Angina
  • Mitral valve prolapse
  • Cardiac
  • Arrhythmias
  • Generalized weakening of the immune system


Ortho Molecular CoQ10
Additional Supplementation

Reacted MultiMin or Reacted Zinc

Dietary Supplements that have Potential for Interactions with Drug (or Drug Class)**

(With ACE Inhibitors and ARBs only): Taking these drugs along with potassium supplements increases risk for hyperkalemia due to a decrease in renal potassium excretion.

(With calcium channel blockers only): Calcium supplements may interfere with the blood pressure lowering activity of these drugs.

Vitamin D:
(Verapamil only, a calcium channel blocker): Vitamin D supplements may interfere with the activity of verapamil.

CoQ10 and Fish Oil:
These supplements may decrease blood pressure in combination with anti-hypertensive drugs. Monitor blood pressure regularly.

Green Tea Catechins and Goldenseal:
These supplements may affect therapeutic benefits of anti-hypertensive drugs.

Garlic, Gingko Biloba, St. John’s Wort:
These supplements have the potential to interfere with the cytochrome P450 system and therefore affect the metabolism and/or clearance of drugs. St. John’s Wort also reduces the bioavailability of Verapamil.

Thiazide diuretics reduce calcium excretion by the kidneys and may increase risk for hypercalcemia, metabolic alkalosis, and possible renal failure.

Melatonin may impair the efficacy of some calcium channel blockers (nifedipine). Monitor for changes in therapeutic efficacy of CCBs and adjust doses as necessary or avoid use of melatonin with this class of drugs.

*Suggested supplements that may support overall health and are not at all intended to replace any prescription medications.

**These supplements listed may have the potential to interact with the drug or drug class. Use caution or avoid these supplements unless approved by your physician or preferred health care provider.